КЛИНИЧЕСКИЕ ОСОБЕННОСТИ ХРОНИЧЕСКОЙ МИГРЕНИ И ИХ ВЛИЯНИЕ НА КОГНИТИВНЫЕ ФУНКЦИИ
Ключевые слова:
хроническая мигрень, когнитивные нарушения, внимание, память, исполнительные функции, нейровоспаление, качество жизни, CGRPАннотация
Данный литературный обзор анализирует клинические особенности хронической мигрени (ХМ) и её влияние на когнитивные функции на основе публикаций 2020–2025 годов из баз данных Google Scholar и Scopus. Поиск проводился в соответствии с руководством PRISMA; в анализ включено 20 статей. Результаты свидетельствуют о значимых нарушениях внимания, памяти, исполнительных функций и скорости обработки информации у пациентов с ХМ, сохраняющихся в межприступный период. Коморбидные депрессия, тревога и расстройства сна дополнительно усугубляют когнитивный дефицит.
Библиографические ссылки
Steiner T.J., Stovner L.J. Global epidemiology of migraine and its implications for public health and health policy. Nat Rev Neurol. 2023; 19(2): 109–117. https://doi.org/10.1038/s41582-022-00763-1
Safiri S. et al. Global, regional, and national burden of migraine in 204 countries and territories, 1990 to 2019. Pain. 2022; 163(3): e293–e309. https://doi.org/10.1097/j.pain.0000000000002275
Ashina M. et al. Migraine. Nat Rev Dis Primers. 2022; 8: 2. https://doi.org/10.1038/s41572-021-00328-4
Fernandes C. et al. Migraine and cognitive dysfunction: a narrative review. J Headache Pain. 2024; 25(1): 221. https://doi.org/10.1186/s10194-024-01923-y
Pizer J.H. et al. Neuropsychological function in migraine headaches: an expanded comprehensive multidomain meta-analysis. Neurology. 2024; 102(4): e208109. https://doi.org/10.1212/WNL.0000000000208109
Cuciureanu D.I. et al. Migraine Comorbidities. Life. 2024; 14(1): 74. https://doi.org/10.3390/life14010074
Rattanawong W., Rapoport A., Srikiatkhachorn A. Neurobiology of migraine progression. Neurobiol Pain. 2022; 12: 100094. https://doi.org/10.1016/j.ynpai.2022.100094
Omaer A. et al. Improvement of comorbid anxiety and depression in patients with migraine treated with injectable preventive CGRP antagonists. Saudi Pharm J. 2024; 32: 101989. https://doi.org/10.1016/j.jsps.2024.101989
Fernandes C., Gil-Gouveia R. Deciphering the mechanisms: Pathophysiology of migraine-related cognitive dysfunction. Cephalalgia. 2025; 45(4). https://doi.org/10.1177/03331024251368328
Cankaya S. et al. Hippocampal connectivity dynamics and volumetric alterations predict cognitive status in migraine: A resting-state fMRI study. NeuroImage. 2025; 305: 120961. https://doi.org/10.1016/j.neuroimage.2024.120961
Gu L., Wang Y., Shu H. Association between migraine and cognitive impairment. J Headache Pain. 2022; 23(1): 89. https://doi.org/10.1186/s10194-022-01462-4
López-Medina D.C. et al. Cognition, mental health, and quality of life in patients with chronic and episodic migraine during the interictal period. BMC Neurol. 2025; 25(1): 108. https://doi.org/10.1186/s12883-025-04122-7
Qin T., Chen C. Cognitive dysfunction in migraineurs. Medicina. 2022; 58(7): 870. https://doi.org/10.3390/medicina58070870
Choudhary A.K. Chronic Migraine and Accelerated Brain Ageing: A Focus on Hippocampal Atrophy, Neuroimaging, and Cognitive Decline. Med Res Archives. 2025; 13(7). https://doi.org/10.18103/mra.v13i7.6728
Coppola G. et al. Pathophysiological bases of comorbidity in migraine. Front Hum Neurosci. 2021; 15: 640574. https://doi.org/10.3389/fnhum.2021.640574
Chen Y.M. et al. Clinical and psychological predictors of sleep quality in chronic migraine. BMC Neurol. 2025; 25: 156. https://doi.org/10.1186/s12883-025-04156-x
Vila-Pueyo M. et al. Advances in understanding migraine pathophysiology: a bench to bedside review. Front Mol Neurosci. 2024; 17: 1355281. https://doi.org/10.3389/fnmol.2024.1355281
Anastasiadou S. et al. Effects of Fremanezumab on psychiatric comorbidities in difficult-to-treat patients with chronic migraine. J Clin Med. 2023; 12(13): 4313. https://doi.org/10.3390/jcm12134313
Wang Y. et al. P2X7R/NLRP3 signaling pathway-mediated pyroptosis and neuroinflammation contributed to cognitive impairment in a mouse model of migraine. J Headache Pain. 2022; 23(1): 75. https://doi.org/10.1186/s10194-022-01443-7
Chen Y.J. et al. Cognitive reserve and its associations with pain, anxiety, and depression in patients with chronic migraine. J Clin Med. 2025; 14(15): 5193. https://doi.org/10.3390/jcm14155193
