IMMUNOLOGICAL CHARACTERISTICS OF PATIENTS WITH COMORBID BRONCHIAL ASTHMA AND TYPE 2 DIABETES MELLITUS
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bronxial astma, 2-tur qandli diabet, IL-6, IL-10, leptin, tizimli yallig‘lanish, IgE, C-reaktiv oqsil, spirometriya##article.abstract##
Maqolada bronxial astma, 2-tur qandli diabet va ularning birgalikdagi kechishi kuzatilgan bemorlarda sitokin profilining xususiyatlari qiyosiy tahlil qilingan. Immun-yallig‘lanish faolligining asosiy mediatorlari sifatida IL-6 va IL-10 darajalari uglevod va lipid almashinuvi ko‘rsatkichlari, leptin, tizimli yallig‘lanish markerlari hamda tashqi nafas olish funksiyasi bilan o‘zaro bog‘liqlikda o‘rganilgan. Statistik tahlil natijasida bronxial astma va 2-tur qandli diabetning birgalikda kechishi IL-10 yallig‘lanishga qarshi sitokini darajasining bir vaqtning o‘zida oshishi bilan kechuvchi eng yaqqol proyallig‘lanish faolligi bilan tavsiflanishi aniqlandi. Yaqin immunometabolik o‘zaro bog‘liqliklar aniqlangan: leptin darajasi IL-6 va IL-10, shuningdek lipid profilining aterogen ko‘rsatkichlari bilan musbat, yuqori zichlikdagi lipoproteinlar darajasi bilan esa manfiy bog‘liqlik ko‘rsatgan. IL-6 darajasi CRP va IgE bilan yaqqol korrelyatsiyalangan, og‘ir giperglikemiya holatida esa uning konsentratsiyasi statistik jihatdan sezilarli darajada yuqori bo‘lgan. Bundan tashqari, IL-6 darajasining oshishi tashqi nafas olish funksiyasi ko‘rsatkichlarining pasayishi bilan kechgan bo‘lib, bu uning o‘pkaning majburiy hayotiy sig‘imi bilan kuchli manfiy korrelyatsiyasi bilan tasdiqlangan. Shunday qilib, bronxial astma va 2-tur qandli diabetning birgalikda kechishi yaqqol immunometabolik fenotipni shakllantiradi, bunda giperglikemiya, dislipidemiya va leptin darajasining oshishi tizimli yallig‘lanishning kuchayishi hamda nafas olish tizimining funksional holati yomonlashuvi bilan bog‘liq.
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