MODERN APPROACHES TO DETECTING ARTHROSIS AT EARLY STAGES AND POSSIBILITIES OF PATHOGENETIC TREATMENT OF THIS DISEASE

Authors

  • GIYASOVA Nigora Qobilovna

Keywords:

gonarthrosis, hyaluronic acid, Synvisc, chondroprotector

Abstract

Introduction: Osteoarthritis is a widespread joint disease requiring effective early diagnosis and treatment. This study evaluates the efficacy of synovial fluid prosthesis in gonarthrosis treatment using MRI and arthroscopy.

Methods: The study involved 86 patients diagnosed with gonarthrosis. The condition of articular cartilage was assessed using arthroscopic and MRI criteria. Patients were divided into experimental and control groups, with Synvisc used in the experimental group and glucocorticoids in the control group.

Results: A positive effect of Synvisc on cartilage tissue was observed at the stages of hyperhydration and early dechondral changes. After 12 months, 51.6% of patients showed complete cartilage restoration. The symptomatic effect lasted longer compared to the control group.

Conclusions: The use of Synvisc in the early stages of gonarthrosis provides significant symptomatic and chondroprotective effects. MRI and arthroscopy proved to be effective in detecting early osteoarthritis stages.

References

Rydell N, Balazs E. Effect of intraarticularinjection of hyaluronic acid on the clinicalsymptoms of osteoartrhritis and on granulation tissue formation. Clin Orthop.1971;80:25–32. DOI:http://dx.doi.org/10.1097/00003086-197110000-00006.

Abatangelo G, Regan MO. Hyaluronan:biological role and function in articularjoints.Eur J Rheum Inflam. 1995;15:916.

Brown TJ, Laurent UB, Fraser JR. Turnoverof hyaluran in synovial joint: elimination oflabelledhyaluronan from the knee joint of therabbit. Exp Physiol.1991;76:125–34.

Ghosh P. The role of hyaluronic acid inhealth and disease: interactions with cells,cartilage and components of the synovialfluid. ClinExpRheumatol. 1994;12:75–82.

Peyron JG. intraarticularhyaluronan injections in the treatment of osteoarthritis.J Rheumatol. 1993;20:105.

Namiki O, Toyoshima H, MorisakiN.Therapeutic effect of intraarticular injectionof high molecular weight hyaluronic acid onosteoarthritis of the knee. Int J ClinPharmacolTherToxicol. 1982;20:501–7.

McDevitt C, Gilberston E, Muir H. Anexperimental model of osteoarthrosis.Earlymorphological and biochemical changes.J Bone Joint Surg. 1977;598:24–35.

Muir H. Current and future trends in articular cartilage research and osteoarthritis. In:Articular cartilage biochemistry. Kuettner K,Schleyerbach R, editors. New York; 1986. P.423–40.

Bayliss MT. Biochemical changes inhuman osteoarthrotic cartilage. In: Studies inosteoarthrosis pathogenesis, intervention,assessment. Lott DJ, Jasani MK, editors.Wiley, Chichester, New York, Brisbane; 1987.P. 46–56.

Altman RD, Tenenbaum J.Biomechanical and biochimical properties ofdog cartilage in experimentally inducedosteoarthritis. Ann Rheum Dis. 1984;43:8390.DOI: http://dx.doi.org/10.1136/ard.43.1.83.

Maroudas A, Katz EP. Physicochemicalproperties and functional behaviour of normal and osteoarthritic human cartilage. In:Articular cartilage biochemistry. KuettnerKE, Schleyerbach R, editors. New York;1986. P. 311–27.

Gardner DL, Mazuryk R.Anatomical changes and pathogenesis ofosteoarthrosis in man, with particular reference to the hip and knee joint. In: Studies inosteoarthrosis pathogenesis, intervention,assessment. Lott DJ, Jasani MK, editors.New York; 1987. P. 21–48.

Mohr W. Pathologie der Gelenke undWeichteiltumoren. In: Arthrosisdeformans/SpeziellePathologie. Doerr W,Seifert G, editors.Berlin, Heidelberg, NewYork; 1984. Bd. 18/1. P. 257–372.

Muir H. Current and future trends inarticular cartilage research and osteoarthritis.In: Articular cartilage biochemistry. KuettnerK, Schleyerbach R, editors. New York; 1986.P. 423–40.

Лучихина ЛВ. Артроскопическая диагностика деформирующего артроза. Терапевтический архив. 1981;53(8):124–6 [Luchikhina LV. Arthroscopic diagnosis of thedeforming arthrosis. Terapevticheskii arkhiv.1981;53(8):124–6. (In Russ.)]

Лучихина ЛВ. Артроз – ранняя диагностика и патогенетическая терапия. В кн.: Медицинская энциклопедия. Москва; 2001. С. 1–167. [Luchikhina LV.Arthrosis – early diagnostics and pathogenetic therapy. In: Meditsinskayaentsiklopediya[Medical encyclopedia]. Moscow; 2001. P.1–167. (In Russ.)]

ЛучихинаЛВ. Возможности артроскопии в диагностике и лечении заболеванийсуставов. В кн.: Тезисы докладов X Европейского конгресса ревматологов. Москва; 1983. С. 91. [Luchikhina LV. Possibilitiesof an arthroscopy in diagnostics and treatmentof diseases of sustava. In: Tezisydokladov XEvropeiskogokongressarevmatologov [Thesesof reports of the X European congress ofrheumatologists]. Moscow; 1983. P. 91]

ЛучихинаЛВ. Артроскопическая диагностика различных стадий деформирующего остеоартроза. В кн.: Тезисы XVI Симпозиума Европейского общества остеоартрологов «Деструкция суставов». 1987. С. 1–12.[LuchikhinaLV. Arthroscopic diagnostics ofvarious stages of the deforming osteoarthrosis.In: Tezisy XVI SimpoziumаEvropeiskogoobshchestvaosteoartrologov «Destruktsiyasustavov» [Theses of XVI Symposiumа of theEuropean society of osteoartrolog «Destructionof joints»]. 1987. P. 1–12]

Luchikhyna LV, Baev AA. Comparison ofthe MRI and arthroscopy for osteoarthrosis inearly diagnostics.Magnetic ResonanceMaterials in Physics, Biology and Medicine.Seville; 1999.Vol. 8.P. 149.

Лучихина ЛВ. Внутрисуставное введение препарата гиалуроновой кислоты после артроскопическоголаважа коленного сустава – отдаленные результаты. Научно-практическая ревматология. 2013;51(1):28–33. [Luchikhina LV. Intraarticular injection of hyaluronic acid after arthroscopic lavage of the knee: longterm results. Nauchno-prakticheskayarevmatologiya = Rheumatology Science and Practice. 2013;51(1):28–33. (In Russ.)]. DOI: http://dx.doi.org/10.14412/1995-4484- 2013-1197.

Abatangelo G, Regan MO. Hyaluronan: Biological role and function in articular joints. Eur J Rheum Inflam. 1995;15:916.

Migliore A, Giovannangeli F, Granata M, Laganа B. Viscosupplementation in the management of ankle osteoarthritis: a review. Arch Orthop Trauma Surg. 2011;131(1):139–47. DOI: http://dx.doi.org/10.1007/s00402-010-1165-5.

Published

2025-06-13