СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О ПАТОГЕНЕЗЕ, ДИАГНОСТИКЕ И КЛАССИФИКАЦИИ МЕДУЛЛОБЛАСТОМЫ (Анализ литературы)
Ключевые слова:
классификация, диагностика, гистология, медуллобластома, SHH, WNTАннотация
Медуллобластома (МБ) является наиболее распространенной эмбриональной опухолью центральной нервной системы, и хотя общий показатель излечения составляет около 70%, у больных, страдающих этим заболеванием, исходы неблагоприятны, а продолжительность заболевания сохраняется длительное время. Диагностика MБ, оценка риска и клиническое значение являются одними из самых быстрорастущих областей нейроонкологии. Эти успехи в основном связаны с технологическими возможностями диагностики и идентификации риска, которые теперь позволяют сочетать гистоморфологическую и молекулярную классификацию. MБ послужит прототипом для других типов опухолей головного мозга в том, как эффективно интегрировать морфологические и геномные данные для стратификации клинико-патологического риска и помочь в разработке инновационных клинических испытаний для доказательной медицины. В данном обзоре анализируются успехи, достигнутые в диагностике и классификации МБ в современных лабораториях нейронаук.
Библиографические ссылки
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