MEDULLOBLASTOMALARNING PATOGENEZI, DIAGNOSTIKASI VA TASNIFLANISHIGA OID ZAMONAVIY QARASHLAR (Adabiyotlar tahlili)
##article.subject##:
klassifikatsiya, diagnoz, gistologiya, medulloblastoma, SHH, WNT##article.abstract##
Medulloblastoma (MB) markaziy asab tizimida eng keng tarqalgan embrional o`sma bo`lib, umumiy davolanish darajasi 70% atrofida bo'lsa-da, kasallik bilan og'rigan bemorlarda salbiy natijalar kuzatilishi va kasallanishning davomiyligi uzoq muddat davom etmoqda. MB diagnostikasi, xavfni va klinikasini baholash eng tez sur'atlar bilan rivojlanayotgan sohalar qatoriga kiradi. Ushbu yutuqlar asosan diagnostika va xavflarni aniqlashtirishdagi texnologik imkoniyatlar bilan bog'liq bo'lib, ular endi gistomorfologik va molekulyar tasnifni birlashtirishga imkon bermoqda. MB kliniko-patologik xavfini tabaqalashtirish uchun morfologik va genomik ma'lumotlarni qanday samarali integratsiya qilish va isbotlangan tibbiyot uchun innovatsion klinik sinovlarni loyihalashda yordam berish bo'yicha boshqa turdagi o'smalar uchun prototip bo'lib xizmat qiladi. Ushbu sharhda zamonaviy neyrologik fanlar laboratoriyalarida MB ning hozirgi kundagi diagnostikasi va tasniflanishi bo’yicha erishilgan yutuqlar tahlil qilingan.
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